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Yamgar, Ramesh S.
- Synthesis and Characterization of Novel Transition Metal Complexes of 4-Methyl-7-Hydroxy 8-Formyl Coumarin and their Biological Activities
Authors
1 Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, IN
2 P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1238-1242Abstract
Novel transition metal Cu(II), Ni(II), Co(II) and Zn(II) ions complexes of bidentate Schiff base ligand obtained from 4-Methyl 7-hydroxy 8-formyl coumarin, and Dimethylamino propylene diamine have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff base act as bidentate ligand for the complexation reaction with Cu(II), Ni(II), Co(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2.2H2O] where [M= Cu(II), Ni(II), Co(II) and Zn(II)] show octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff base and their metal complexes have been screened for antimicrobial activity. The transition metal complexes have shown enhanced antimicrobial activities as compared to Schiff base.Keywords
Schiff Bases, 4-Methyl 7-Hydroxy 8-Formyl Coumarin, Transition Metal Complexes.
- Synthesis and Characterization of Novel Transition Metal Complexes of Benzo-α-Pyranone Derivatives and their Biological Activities
Authors
1 Department of Chemistry, Patkar College of Arts and Science, Goregaon (W), Mumbai 400 062, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 834-837Abstract
Some novel transition metal [Mn(II), Co(II), Ni(II), Cu(II), Pd(II)] complexes of multidentate Schiff base ligand obtained from semicarbazide and substituted α-benzopyronone have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff base act as tridentate ligand for the complexation reaction with Mn(II), Co(II), Ni(II), Cu(II) and Pd(II) ions. The new compounds, possessing the general formula [M(L)2.H2O] where [M= Mn(II), Co(II), Ni(II), Cu(II) and Pd(II)] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff base and their metal complexes have been screened for antimicrobial activity. The transition metal complexes have shown enhanced antimicrobial activities as compared to Schiff base.Keywords
Schiff Bases, α-Benzopyrone, Transition Metal Complexes.- Method Development and Validation of Stability indicating HPLC method used for the estimation of Degradation Products of Atorvastatin Calcium
Authors
1 Chemistry Research Laboratory, Patkar-Varde College, Goregaon (W), Mumbai-400 062, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 551-554Abstract
A simple, fast and precise gradient reversed phase high performance liquid chromatographic method was developed for the estimation of impurities and degradation products of the Atorvastatin Calcium and validated as per ICH guidelines. The drug substance, its impurities and degradation products were found well separated with gradient conditions having short run time of 35 mins by using Symmetry C18 column from Water’s (250 x 4.6 mm, 5μm). The flow rate was kept 1 mL/min. The gradient mobile phase consisted of A= 0.05% Trifluoroacetic acid in water and B= 0.05% Trifluoroacetic acid in Acetonitrile. Detection was performed at 249 nm using PDA detector.
The method was validated for Specificity, LOD, LOQ, Linearity and Accuracy as per ICH guidelines. The stability indicating capability of the method was established by performing forced degradation study. The proposed method was found to be accurate, precise and fast for the estimation of Atorvastatin, its impurities and degradation products.